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恶性综合征(NMS)是一种抗精神病药物治疗时潜在的致死性并发症。由于该病是由具有高效抗多巴胺作用的神经阻滞剂引起,近来人们的注意力已集中到中枢多巴胺活动减退与 NMS 发病机理二者之间的关系上,即 NMS 可能是由于纹状体和下丘脑的多巴胺活动降低所致,为了充分证实这一理论,作者测定了8例 NMS 患者 CSF 中多巴胺代谢物高香草酸(HVA)和5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NA)和3-甲氧-4
Malignant syndrome (NMS) is a potentially fatal complication of antipsychotic treatment. Since the disease is caused by a neuroprotective agent that is highly potent anti-dopamine, attention has recently been focused on the relationship between central dopamine disfunction and the pathogenesis of NMS, which may be due to striatum and To fully substantiate this hypothesis, we hypothesized that hypothalamic dopamine activity may be reduced. To determine this hypothesis, the authors determined dopamine metabolites such as homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA), noradrenal (NA) and 3-methoxy-4