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目的探讨依那普利叶酸辅助治疗对急性脑梗死合并高血压患者预后的影响。方法选取2015年7月—2016年10月郑州大学附属洛阳中心医院收治的76例急性脑梗死合并高血压患者作为研究对象,依据辅助治疗用药不同,分为对照组(n=38)与研究组(n=38),对照组行马来酸依那普利进行治疗,研究组行依那普利叶酸进行治疗,比较两组治疗8周后Barthel评分、NIHSS评分、同型半胱氨酸(Hcy)以及血压值。结果观察组治疗4周与治疗8周Barthel评分明显高于对照组,且治疗4周与治疗8周NIHSS评分、收缩压(SBP)、舒张压(DBP)及血浆Hcy明显低于对照组(P<0.05)。结论对急性脑梗死合并高血压患者予以依那普利叶酸辅助治疗,可有效降低血浆Hcy与血压值,改善患者生存能力与神经功能缺损情况。
Objective To investigate the effect of enalapril-based folic acid adjuvant therapy on the prognosis of patients with acute cerebral infarction complicated with hypertension. Methods From July 2015 to October 2016, 76 patients with acute cerebral infarction and hypertension were admitted to Luoyang Central Hospital Affiliated to Zhengzhou University. According to the different adjuvant therapy, they were divided into control group (n = 38) and study group (n = 38). The control group was treated with enalapril maleate. The study group was treated with enalapril folate. The Barthel score, NIHSS score, homocysteine (Hcy) ) And blood pressure values. Results The Barthel score of the observation group was significantly higher than that of the control group at 4 weeks and 8 weeks of treatment. NIHSS score, SBP, DBP and Hcy in the 4 weeks and 8 weeks of treatment were significantly lower than those in the control group (P <0.05). Conclusions Enalapril folate supplementation in patients with acute cerebral infarction complicated with hypertension can effectively decrease plasma Hcy and blood pressure and improve patients’ survival ability and neurological deficit.