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目的:探讨多烯磷脂酰胆碱治疗老年中重度脂肪肝临床疗效及安全性。方法:将2014年2月-2017年2月在我院消化内科治疗的90例老年中重度脂肪肝患者随机分为两组,对照组采用常规调脂及保肝治疗,在此基础上观察组采用多烯磷脂酰胆碱治疗,比较两组患者的治疗效果、肝功能指标。结果:观察组治疗有效率为93.18%,明显高于对照组的71.11%,差异有统计学意义(P<0.05);观察组治疗后ALT、AST、TBIL、DBIL、ALB等明显较对照组改善,差异有统计学意义(P<0.05)。结论:多烯磷脂酰胆碱治疗老年中重度脂肪肝临床疗效显著,能有效改善肝功能,且不良反应轻微,具有积极的临床意义。
Objective: To investigate the clinical efficacy and safety of polyene phosphatidylcholine in the treatment of senile moderate-severe fatty liver. Methods: 90 elderly patients with moderate to severe fatty liver disease who underwent gastroenterology in our hospital from February 2014 to February 2017 were randomly divided into two groups. The control group was treated with conventional lipid-lowering and hepatoprotective therapy. On the basis of this observation group The treatment of polyene phosphatidylcholine, the treatment effect of two groups of patients, liver function indicators. Results: The effective rate of observation group was 93.18%, which was significantly higher than that of control group (71.11%), the difference was statistically significant (P <0.05); ALT, AST, TBIL, DBIL, , The difference was statistically significant (P <0.05). Conclusion: Polyene phosphatidylcholine treatment of senile moderate and severe fatty liver clinical significant effect, can effectively improve liver function, and minor adverse reactions, has a positive clinical significance.