FK778是抗风湿药物来氟米特的活性代谢产物A771726的衍生物,它具有比母体更高的免疫效能及更短的半衰期,主要通过抑制二氢乳酸脱氢酶阻断嘧啶的从头合成,发挥其抑制T、B淋巴细胞增殖的作用。作为新一代器官移植的理想药物,它能抑制急性排斥反应,减轻慢性排斥反应,推迟移植物慢性 FK778 is a derivative of the active metabolite of the anti-rheumatic drug leflunomide, A771726, which has higher immunogenicity and shorter half-life than the parent, and inhibits de novo synthesis of pyrimidine mainly by inhibiting dihydrogen lactate dehydrogenase Its inhibition of T, B lymphocyte proliferation. As a new generation of organ transplant ideal drug, it can inhibit acute rejection, reduce chronic rejection, delayed graft chronic