目的　提高对药物性肝损害的早期诊断水平 ,减少其发病率和病死率。方法　对 81例药物性肝损害病人进行临床分析。结果　药物性肝损害病人占同期住院肝病病人的 0 96 %。致肝损害的药物种类多 ,临床类型以急性肝损害为主 (73例 )。治愈 62例 ,好转 1 4例 ,恶化自动出院及死亡 5例。结论　临床上慎用对肝脏有损害的药物 ,用药期间严密观察 ,早期诊断是良好预后的关键 Objective To improve the early diagnosis of drug-induced liver damage and reduce its morbidity and mortality. Methods 81 cases of drug-induced liver damage in patients with clinical analysis. Results Drug-induced liver damage accounted for 0 96% of hospitalized patients with liver disease over the same period. Liver damage caused by many types of drugs, the main clinical type of acute liver injury (73 cases). 62 cases were cured, 14 cases improved, and 5 cases were discharged automatically and died. Conclusion Clinical caution with liver damage drugs, closely observed during the medication, early diagnosis is the key to good prognosis