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为克服细菌对抗菌素的耐药性,利用“突击性”大剂量青霉素,有的一昼夜剂量增至6000万单位以上;但是剂量过大有可能抑制机体的免疫反应。作者研究大剂量青霉素对青霉素耐药致病菌引起的大白鼠下颌炎症的作用,以及同时注射胸腺素(从牛的胸腺中提出的多肽复合物)对大白鼠感染性炎症的影响。研究材料和方法:107只大白鼠,体重150～180g。从牙源性下颌骨骨髓炎病人分离出对青霉素耐药的致病葡萄球菌,培养一昼夜,把含6亿致病菌的生理盐水0.3ml注射到动物左下颌骨膜下,引起感染性炎症。然后把动物分为3组,第1组是对照组35只,从实验第4天每天肌肉注射生理盐水
To overcome the bacterial resistance to antibiotics, the use of “assault” high-dose penicillin, and some day and night doses increased to 60 million units or more; but the dose is too large may inhibit the body’s immune response. The authors investigated the effect of high-dose penicillin on penile inflammation induced by penicillin-resistant pathogens in rats and the effects of simultaneous injection of thymosin (polypeptide complex presented in the thymus of the cow) on infectious inflammation in rats. Materials and Methods: 107 rats, weighing 150 ~ 180g. Staphylococcus aureus resistant to penicillin was isolated from patients with odontogenic mandibular osteomyelitis and injected with 0.3 ml of saline containing 600 million pathogenic bacteria into the left mandibular periosteum of animals for one day and night to cause infectious inflammation. Then the animals were divided into 3 groups, the first group is the control group of 35, 4 days a day from the experimental intramuscular injection of saline