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用电化学的方法，研究环丙沙星（ＣＰＦＸ）及其镁、锰络合物与脱氧核糖核酸（ＤＮＡ）的相互作用及其极谱伏安行为。结果在０１ｍｏｌ·Ｌ－１ＮＨ３ＮＨ４Ｃｌ（ｐＨ９２）溶液中，环丙沙星可与ＤＮＡ作用，产生一新的极谱峰Ｅｐ＝－１７２Ｖ（ｖｓＡｇ／ＡｇＣｌ），在有Ｍｇ２＋或Ｍｎ２＋存在时则生成三元络合物，产生一电位更负的新峰，峰电位Ｅｐ＝－１７８Ｖ，提示Ｍｇ２＋或Ｍｎ２＋离子参与药物与ＤＮＡ的作用。对它们的还原峰性质研究表明，电极还原反应是完全不可逆的，电流具有吸附性。本文还探讨了电极还原机理，认为参与电极还原的是三元络合物中的环丙沙星分子，进一步推测ＣＰＦＸＭｇ是嵌入ＤＮＡ的双螺旋结构中。
The interaction between CPFX and its magnesium and manganese complexes with DNA and its polarographic voltammetric behavior were studied electrochemically. Results In 0.1mol·L-1NH3-NH4Cl (pH92) solution, ciprofloxacin could interact with DNA to produce a new polarographic peak Ep = -172V (vsAg / AgCl) Or Mn2 +, ternary complex was formed, resulting in a new peak with more negative potential. The peak potential Ep = -178V, suggesting that Mg2 + or Mn2 + ions participate in the interaction between drugs and DNA. Studies on their reduction peak properties show that the electrode reduction reaction is completely irreversible and the current is adsorptive. This paper also discusses the electrode reduction mechanism, that is involved in the electrode reduction is ternary complex ciprofloxacin molecules, and further speculated that CPFX Mg is embedded in the DNA double helix structure.