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目的了解和研究长期应用国产低剂量口服避孕药(OC)与使用者衣原体(CT)感染的关系。方法采用聚合酶链反应(PCR)检测服用避孕药或使用宫内节育器5年以上的妇女224人宫颈分泌物中CTDNA。结果三组研究对象的CT检出率为21.24%,三组中CT检出率1号片组最高,对照组最低,分别为1号片组24.69%、复方18甲组20.45%、对照组17.54%,服药组均高于对照组,CT检出率三组间的差别无显著性(P>0.05)。服药组不同类型的避孕药使用者中CT感染的检出率也不相同,1号片组CT感染高于复方18-甲组,这可能与COC中雌孕激素的配伍不同有关,1号片中的雌孕激素均高于复方18-甲组,与雌孕激素的共同作用而导致CT感染率增加。口服避孕药者中CT的感染引起的宫颈异常高于对照组,但无显著差异,多数感染者并无临床体征。结论长期服用避孕药者CT感染略有升高。对有性生活,特别是长期使用口服避孕药的妇女提供相应的随访和检测服务,以提高避孕药使用者的生殖健康水平。
Objective To understand and study the long-term application of low-dose oral contraceptives (OC) and the relationship between chlamydia (CT) infection. Methods CTDNA of 224 cervical secretions of women who took contraceptives or who had used IUD for more than 5 years were detected by polymerase chain reaction (PCR). Results The detection rate of CT in the three groups was 21.24%. The detection rate of CT in the three groups was the highest, the lowest in the control group, which was respectively 24.69% in the No.1 group, 20.45% in the 18 A group, 17.54% in the control group %, Medication group were higher than the control group, CT detection rate was no significant difference between the three groups (P> 0.05). The detection rate of CT infection in different types of contraceptive users in the medication group was also different, and the CT infection in group 1 was higher than that in group 18-A, which may be related to the different compatibility of estrogen and progesterone in COC. In the estrogen and progesterone are higher than the compound 18- A group, and the combined effect of estrogen and progesterone lead to CT infection increased. Oral contraceptives in CT infection caused by cervical abnormalities higher than the control group, but no significant difference, most infected with no clinical signs. Conclusion Long-term use of contraceptives CT infection increased slightly. Provide appropriate follow-up and testing services for women who have sex life, especially long-term use of oral contraceptives, in order to improve the reproductive health of contraceptive users.