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0 引言 骨形成蛋白 (BMP)受体有 I型和 II型两种 ,属于TGF- β受体超家族成员 ,都具有丝氨酸 /苏氨酸蛋白激酶活性 .人 BMP II型受体 c DNA全长 3871bp,编码 10 39个氨基酸的蛋白 ,包括 12 5个氨基酸的胞外区 [1 ] . TGF-β超家族信号转导的一般模式为 :配体先与 II型受体结
0 Introduction Bone morphogenetic protein (BMP) receptors are type I and II and belong to members of the TGF-beta receptor superfamily with serine / threonine protein kinase activity. Human BMP type II receptor c-DNA full length 3871 bp, encoding a protein of 399 amino acids, including the extracellular region of 125 amino acids [1] .General patterns of signal transduction of the TGF-β superfamily are that the ligand first interacts with the type II receptor