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目的 研究~(99m)Tc-MIBI在乳腺癌及良性病变中的浓聚与细胞增殖及血管形成的关系,探讨乳房~(99m)Tc-MIBI阳性显像的机理和临床意义。材料与方法 从1995年4月至1996年2月,我们选择了38例因乳房肿块在我院治疗的女性病人进行研究,年龄49.03±11.31岁（x±S）,其中乳腺癌22例,良性病变16例。病人术前行俯卧位乳房~(99m)Tc-MIBI阳性显像,在注射~(99m)Tc-MIBI 740 MBq后10 min,取患侧后斜位10度测定放射性核素浓聚灶与周围正常组织的放射性比值（以下略为比值）。术后在病灶与正常乳腺组织交界处取材后,送常规病理检查和增殖细胞核抗原（proliferating cell nuclear antigen,PC-NA）、荆豆凝集素（ulex europaeus I lectin,UEA-I）等免疫组化染色（ABC法）。分别计算病灶中PCNA阳性细胞百分数和400×视野下UEA—I染色阳性血管的条数。数据采用t检验;计算Spearman相关系数和多元线性回归进行分析。结果 38例病人常规病理检查诊断为恶性肿瘤的22例,良性病变的16例,显像结果:真阳性17例;真阴性15例;假阳性二例;假阴性5例（X~2=18.74 P<0.001）。乳房~(99m)Tc-MIBI显像阳性组和阴性组之间肿块直径、PCNA百分数有显著差异;而血管条数的差异不明显。放射性比值和肿块直径、血管条数和PCNA百分数之间的相关系数分别?
Objective To investigate the relationship between the concentration of ~(99m)Tc-MIBI in breast cancer and benign lesions and the relationship between cell proliferation and angiogenesis, and to explore the mechanism and clinical significance of ~(99m)Tc-MIBI positive imaging of breast. Materials and Methods From April 1995 to February 1996, we selected 38 women with breast lumps treated in our hospital. The age was 49.03±11.31 years (x±S), of which 22 were breast cancers. 16 cases of lesions. The patients were performed preoperatively with 99m Tc-MIBI positive imaging in the prone position. 10 min after the injection of ~(99m)Tc-MIBI 740 MBq, the ipsilateral posterior oblique position was measured at 10 degrees to determine the concentration of radionuclide concentrators. Radiation ratio of normal tissue (slightly ratio below). After the lesions were harvested from the junction of normal breast tissue, routine pathological examinations, proliferating cell nuclear antigen (PC-NA), and eugenic leukolectin (UEA-I) immunohistochemistry were performed. Staining (ABC method). The percentage of PCNA-positive cells in the lesion and the number of UEA-I-positive vessels in the 400× field were calculated. Data were analyzed using t-tests; Spearman correlation coefficients and multiple linear regressions were calculated. Results Twenty-two cases of malignant tumors and 16 cases of benign lesions were diagnosed by routine pathological examination in 38 cases. The results were: true positive in 17 cases; true negative in 15 cases; false positive in 2 cases; false negative in 5 cases (X~2=18.74). P<0.001). There was a significant difference in the diameter of the tumor and the percentage of PCNA between the positive 99m Tc-MIBI imaging group and the negative group; however, there was no significant difference in the number of vessels. The correlation coefficient between the radioactivity ratio and the diameter of the tumor, the number of blood vessels, and the percentage of PCNA?