Berardinis等曾证实,源自糖尿病患者的CD4—阳性T细胞克隆能溶解与HLA-Ⅱ相匹配的胰岛细胞。他们强调这一过程可能在Ⅰ型糖尿病的发生机理中很重要。 当然,依据单项实验去推测其发病学不一定可靠。激活T细胞受体后,通过抗—Vβ8抗体而生长于体外的CD4阳性细胞克隆,以及从近期诊断的糖尿病人循环外周血的该细胞,能溶解(在体外)与HCA Berardinis et al have demonstrated that CD4-positive T cell clones derived from diabetic patients can dissolve islet cells that are compatible with HLA-II. They emphasize that this process may be important in the pathogenesis of type 1 diabetes. Of course, based on a single experiment to speculate that its pathogenesis is not necessarily reliable. After activation of T-cell receptors, CD4-positive cell clones that grow in vitro by anti-Vβ8 antibodies, as well as from peripheral blood from recently diagnosed diabetic patients, can lyse (in vitro)