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暴发性肝炎的病因主要有A、B、D、E型肝炎病毒和毒素,HCV并非暴发性非甲非乙型肝炎的病因。为弄清暴发性非甲非乙型肝炎的病因,作者调查了26名暴发性肝炎肝移植病人,采用两步多聚酶链反应(PCR)检测病人血清和肝标本中HBV表面和核心编码区DNA。17名病人诊断为暴发性非甲非乙型肝炎。在肝移植前,17名病人无任何急性HBV感染的血清学证据。肝脏移植后,3名病人血清学检测HBsAg和HBeAg均为阳性。
The causes of fulminant hepatitis are mainly A, B, D, and E hepatitis viruses and toxins, and HCV is not the cause of fulminant non-A, non-B hepatitis. To clarify the etiology of fulminant non-A, the authors investigated 26 patients with fulminant hepatitis and two-step polymerase chain reaction (PCR) was used to detect the HBV surface and core coding region DNA in patient serum and liver samples. Seventeen patients were diagnosed with fulminant non-A, non-B hepatitis. Before liver transplantation, 17 patients had no serological evidence of any acute HBV infection. After liver transplantation, serological tests of 3 patients were positive for both HBsAg and HBeAg.