男患,48岁,右下肢间隙性跛行一年余,渐加重,右足背肿痛伴第二、三趾干性坏疽一周入院。诊断为右下肢血栓闭塞性脉管炎。无药物过敏史,非过敏体质,曾接受右旋糖酐治疗。入院后首次静滴低分子右旋糖酐不到5分钟,患者出现胸闷、心慌、全身皮肤潮红、皮肤 Male, 48 years old, right lower limb laxity lame more than a year, getting heavier, right back and back pain with the second, three-week dry gangrene week hospitalization. Diagnosis of right lower extremity thromboangiitis obliterans. No history of drug allergy, non-allergic, had received dextran treatment. For the first time after admission intravenous low molecular weight dextran less than 5 minutes, patients with chest tightness, palpitation, systemic skin flushing, skin