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前言阿斯匹林和其它非类固醇抗炎症药物对系统性红斑狼疮(SLE)患者特别是肾炎的临床症状明显的患者能降低其肾小球滤过率(GFR)。因为前列腺素能影响肾的循环,所以提出抑制前列腺素的合成是引起此种效应的机制。但是,给予阿斯匹林和消炎痛于正常人和类风湿性关节炎患者引起GFR的改变是不同的。SLE患者之所以对阿斯匹林和有关药物有较大的易感性仍未能解释。假设尽管初步证明在麻醉动物,前列腺素对肾的自身调节是重要的,但对神志清楚的动物,
Introduction Aspirin and other non-steroidal anti-inflammatory drugs reduce glomerular filtration rate (GFR) in patients with significant clinical symptoms of systemic lupus erythematosus (SLE), especially nephritis. Because prostaglandins can affect renal circulation, it is proposed that inhibition of prostaglandin synthesis is the mechanism by which this effect occurs. However, administration of aspirin and indomethacin to GFR in patients with rheumatoid arthritis and normal subjects is different. The reason why SLE patients are more susceptible to aspirin and related drugs remains unexplained. It is hypothesized that although prima facie evidence of autonomic regulation of the kidney by prostaglandins is important in anesthetized animals, for conscious animals,