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目的 :探讨碱性成纤维细胞生长因子 (bFGF)与膀胱癌发生发展的关系。方法 :应用免疫组化方法检测了 4 8例膀胱癌存档标本和 4例正常膀胱组织中bFGF的蛋白表达。结果 :4 8例膀胱癌存档蜡块中有 2 3例阳性 ,浸润性癌显著高于浅表癌 (P <0 .0 1) ,除G1和G2 之间外各分级阳性率之间差异也有显著性。阳性着色定位于肿瘤细胞、血管内皮细胞、正常逼尿肌及肿瘤基质。结论 :bFGF可能通过自分泌和旁分泌机制诱导膀胱癌血管生成 ,或通过胞内分泌作用刺激某些酶的产生 ,从而促进肿瘤的浸润。bFGF高表达对预测膀胱癌患者的复发和预后有一定的指导意义。拮抗bFGF的作用可能是治疗和预防膀胱癌复发和转移的一条新途径。
Objective: To investigate the relationship between basic fibroblast growth factor (bFGF) and the development of bladder cancer. Methods: Immunohistochemistry was used to detect the protein expression of bFGF in 48 specimens of bladder cancer and 4 cases of normal bladder tissues. RESULTS: Twenty-three of the 48 cases of bladder cancer preserved paraffin wax were positive and invasive carcinoma was significantly higher than that of superficial carcinoma (P <0.01). There was also a difference between the positive rates of G1 and G2 Significance. Positive staining located in tumor cells, vascular endothelial cells, normal detrusor and tumor stroma. CONCLUSION: bFGF may induce angiogenesis of bladder cancer through autocrine and paracrine mechanisms or stimulate the production of certain enzymes through endocrine function, thereby promoting tumor invasion. bFGF overexpression is of guiding significance in predicting the recurrence and prognosis of patients with bladder cancer. Antagonism of the role of bFGF may be a new way to treat and prevent the recurrence and metastasis of bladder cancer.