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碳-杂键对炔键的加成反应已经成为对碳碳叁键进行官能团化的一种重要手段,此类反应可以一步快速构建两个化学键即一个碳-碳键和一个碳-杂键,因而具有反应效率高、原子经济性高的特点.近年来,Al,Fe,Ni,Cu,Ga,Ru,Rh,Pd,Hf,Ir,Pt,Au,Bi等催化的诸多类型的碳-杂键对炔键的加成反应取得了重要进展.根据对炔键进行加成的碳-杂键的类型分为C—H,C—B,C—N,C—O,C—Si,C—S,C—X(X=Cl,Br,I),C—Se键这8类逐一进行介绍,并对各类加成反应的反应条件、反应选择性(区域选择性和立体化学选择性)以及反应机理进行了讨论和总结.
The addition reaction of carbon-hetero bond to acetylenic bond has become an important means to functionalize carbon-carbon triple bond. Such reaction can rapidly build two chemical bonds, namely one carbon-carbon bond and one carbon-hetero bond in one step, So it has the characteristics of high reaction efficiency and high atom economy.In recent years, many kinds of carbon-miscellaneous compounds catalyzed by Al, Fe, Ni, Cu, Ga, Ru, Rh, Pd, Hf, Ir, Pt, Au, Significant progress has been made in the addition reaction of the bond to the acetylenic bond, which is classified into C-H, C-B, C-N, C-O, C-Si, C -S, C-X (X = Cl, Br, I) and C-Se bonds. The reaction conditions, reaction selectivity ) And reaction mechanism were discussed and summarized.