20世纪初,当给患有恶性肿瘤的患者接种狂犬病疫苗后肿瘤消退,使人们首次认识到可以用病毒治疗肿瘤。到了2 0年代,动物实验证实了病毒的感染能力及溶解小鼠的实体肿瘤的能力。5 0年代,又有实验研究报道展示了流感病毒、新城疫病毒(NDV)对小鼠的EAC(Ehrlich′sascitescarcinoma) At the beginning of the 20th century, when the rabies vaccine was administered to patients with malignant tumors, the tumor subsided, making it the first time people realized that they could treat the tumor with the virus. By the 20s, animal experiments confirmed the ability of the virus to infect and solid tumors in mice. In the 1950s, another experimental study showed that the influenza virus, Newcastle disease virus (NDV) on mouse EAC (Ehrlichsascitescarcinoma)