目的探讨可以早期预测脓毒症预后的临床指标。方法前瞻性观察脓毒症患者28 d,分析与预后相关的临床指标。结果共观察42例,其中19例(45%)死亡。一些临床指标水平在死亡者或生存者间差别较大,其中包括血总胆红素、血 pH值、红细胞压积、氧合指数、动静脉血氧差(AVDO_2)、四项全身炎症反应综合征(SIRS)指标积分和血流动力学指标等。结论脓毒症时感染所引起的全身炎症反应紊乱、酸中毒和缺氧状态影响患者的生存。脓毒症发生初期的一些临床指标水平有助于早期进行预后评估。 Objective To investigate the clinical predictive value of early prediction of sepsis. Methods Prospective observation of patients with sepsis 28 d, analysis and prognosis of clinical indicators. Results A total of 42 cases were observed, of which 19 (45%) died. Some clinical indicators of the level of death or survivors vary widely, including blood total bilirubin, blood pH, hematocrit, oxygenation index, arteriovenous oxygen difference (AVDO_2), four systemic inflammatory response Sign (SIRS) indicators integral and hemodynamic indicators. Conclusion The systemic inflammatory response caused by sepsis infection is disturbed. The acidosis and hypoxia affect the survival of patients. Some clinical indicators of the early stages of sepsis help to assess the prognosis early.