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目的 :探讨新鲜羊膜移植在治疗严重的急、慢性眼表疾病中重建健康眼表的可行性 ,评价其疗效。方法 :本院住院的眼表疾病患者 2 1例 (2 2只眼 )分别进行单纯羊膜移植术 13例 (14只眼 )、羊膜移植结膜囊成形术 2例 (2只眼 )和羊膜移植联合自体角膜缘干细胞移植术 6例 (6只眼 )。术后随访 6～ 12个月 ,平均 8 5个月。结果 :所有移植的羊膜植片均未出现溶解和排斥 ,2 1例术后视力均提高。角膜溃疡患者未见角膜继续溶解 ,睑球粘连患者恢复眼球运动功能 ,翼状胬肉未见复发。结论 :新鲜羊膜移植可有效应用于重建眼表面 ,有一定的临床推广价值。
Objective: To investigate the feasibility of fresh amniotic membrane transplantation for the reconstruction of healthy ocular surface in the treatment of severe acute and chronic ocular surface diseases and to evaluate its curative effect. Methods: Twenty-one patients (22 eyes) hospitalized with ocular surface disease were treated with simple amniotic membrane transplantation in 13 cases (14 eyes), amniotic membrane transplantation conjunctivoplasty in 2 cases (2 eyes) combined with amniotic membrane transplantation Six limbal stem cell autografts (6 eyes) were performed. The patients were followed up for 6 to 12 months with an average of 85 months. Results: All the transplanted amniotic membrane showed no dissolution and rejection, and 21 patients had improved visual acuity. Corneal ulcer patients did not continue to dissolve the cornea, symblepharon patients to restore eye movement, no recurrence of pterygium. Conclusion: Fresh amniotic membrane transplantation can be effectively used to reconstruct the ocular surface, which has certain clinical value of popularization.