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本文研究了当归提取物LIG的抗炎,解热活性。研究发现LIG(2.5,5,10 mg/kg)对角叉菜和右旋糖苷诱导的足肿胀的抑制率分别为22.2%,49.4%,76.5%和20.8%,44.2%,75.3%(P<0.001);对棉球肉芽肿的抑制率为29.2%,44.9%,58.8%(P<0.001);对小鼠白细胞迁移的抑制率为20.7%,35.6%,48.2%(P<0.001)。此外,LIG可降低啤酒酵母导致的高热(P<0.001)。并且,LIG的抗炎,解热作用均成剂量依赖性。以上结果显示LIG具有非常强的抗炎,解热活性。
This article studied the anti-inflammatory, antipyretic activity of Angelica extract LIG. The study found that the inhibitory rates of LIG (2.5, 5, 10 mg/kg) on foot swelling induced by carrageenan and dextran were 22.2%, 49.4%, 76.5% and 20.8%, 44.2%, and 75.3%, respectively (P< 0.001); inhibition rate of cotton ball granuloma was 29.2%, 44.9%, 58.8% (P <0.001); inhibition rate of mouse leukocyte migration was 20.7%, 35.6%, 48.2% (P <0.001). In addition, LIG reduced the high fever caused by brewer’s yeast (P<0.001). Moreover, the anti-inflammatory and antipyretic effects of LIG were dose-dependent. The above results show that LIG has a very strong anti-inflammatory, antipyretic activity.