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目的分析显微手术在脑胶质瘤中的应用及其对脑脊液精氨酸加压素(AVP)、催产素(OT)、β-内啡肽(β-EP)、肿瘤细胞坏死因子-α(TNF-α)表达水平的影响。方法收集脑胶质瘤患者86例,按分层随机分组法将患者随机分为对照组和研究组,每组各43例。对照组行传统手术治疗,研究组行显微手术治疗,比较两组患者的手术时间、住院时间、AVP、OT、β-EP、TNF-α表达水平及并发症发生情况。结果研究组手术时间和住院时间短于对照组,差异有统计学意义(P﹤0.05);治疗后两组患者AVP、OT、β-EP、TNF-α水平均较治疗前降低,研究组患者AVP、OT、β-EP水平高于对照组,TNF-α水平低于对照组(P﹤0.05);研究组并发症发生率低于对照组(P﹤0.05)。结论显微手术在脑胶质瘤中的临床效果确切,利于脑脊液AVP、OT、β-EP、TNF-α恢复。
Objective To analyze the application of microsurgery in gliomas and its effect on cerebrospinal fluid of AVP, OT, β-EP, tumor necrosis factor-α (TNF-α) expression levels. Methods Totally 86 patients with glioma were enrolled. Patients were randomly divided into control group and study group according to stratified randomization method, with 43 cases in each group. The control group received conventional surgery and the study group underwent microsurgical treatment. The operation time, hospitalization time, AVP, OT, β-EP, TNF-α expression levels and complications were compared between the two groups. Results The operation time and hospital stay in the study group were shorter than those in the control group (P <0.05). After treatment, the levels of AVP, OT, β-EP and TNF-α in both groups were lower than those before treatment The levels of AVP, OT and β-EP were higher in the control group than those in the control group (P <0.05). The incidence of complications in the study group was lower than that in the control group (P <0.05). Conclusions The microsurgery is clinically effective in glioma and is beneficial to the recovery of AVP, OT, β-EP and TNF-α in cerebrospinal fluid.