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目的:对头孢哌酮/舒巴坦联合中药在泛耐药鲍曼不动杆菌(PDR-AB)抗菌活性进行分析探究。方法:采用K-B法选出泛耐药鲍曼不动杆菌50株,根据微量肉汤稀释方法对单独头孢哌酮/舒巴坦与头孢哌酮/舒巴坦联合中药两种方法中药物的最小抑菌浓度(MIC)情况进行检测,并计算抑菌浓度指数(FIC)情况。结果:头孢哌酮/舒巴坦联合中药方法中,两种药物联合对泛耐药鲍曼不动杆菌(PDR-Ab)的MIC_(range)(7.32±0.25)μg/ml、MICG(5.42±0.48)μg/ml与单独头孢哌酮/舒巴坦药物对PDR-Ab的MIC_(range)(11.54±0.31)μg/ml、MICG(12.47±0.42)μg/ml相比明显减小,差异有统计学意义(t=74.9282、78.1598,p=2.4855×10-88、4.2424×10-90)。结论:单独应用头孢哌酮/舒巴坦抑制泛耐药鲍曼不动杆菌(PDR-AB)抗菌活性的效果并不是十分显著,将该药物与中药联合应用后,显著降低了最小抑菌浓度,两种药物发挥协同作用,具有重要临床意义,值得广泛推广。
OBJECTIVE: To study the antibacterial activity of cefoperazone / sulbactam combined with Chinese traditional medicine on Acinetobacter baumannii (PDR-AB). Methods: Fifty strains of Pan-drug-resistant Acinetobacter baumannii were selected by KB method. According to the method of micro-broth dilution, the combination of cefoperazone / sulbactam and cefoperazone / sulbactam alone was the best Bacteriostatic concentration (MIC) were detected, and antibacterial concentration index (FIC) was calculated. Results: In the cefoperazone / sulbactam combined with traditional Chinese medicine (TCM) method, the combination of the two drugs against MIC-range (7.32 ± 0.25) μg / ml of pan-drug resistant Acinetobacter baumannii (PDR-Ab) 0.48) μg / ml was significantly lower than MIC range (11.54 ± 0.31) μg / ml and MICG (12.47 ± 0.42) μg / ml for PDR-Ab with cefoperazone / sulbactam alone Statistical significance (t = 74.9282, 78.1598, p = 2.4855 × 10-88, 4.2424 × 10-90). CONCLUSION: Cefoperazone / sulbactam alone is not effective in inhibiting the antibacterial activity of pan-drug-resistant Acinetobacter baumannii (PDR-AB). The combined use of this drug and traditional Chinese medicine significantly reduced the minimum inhibitory concentration , Two drugs play a synergistic effect, has important clinical significance, it is worth to be widely promoted.