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目的了解2型糖尿病患者中踝臂血压指数(ABI)与尿白蛋白与肌酐比值(UACR)的相关性。方法收集自2009-01-2011-01在我院内分泌科住院的2型糖尿病患者共469例,测定ABI及其他相关指标。选取同期在我院门诊体检者38例为正常对照组。研究2型糖尿病患者ABI异常与UACR的相关性。结果 469例2型糖尿病患者尿蛋白异常率62.7%,ABI异常率42.6%。临床蛋白尿组、微量蛋白尿组、尿蛋白正常组3组患者的ABI异常率分别为41.4%、23.2%、14.9%。ABI≤0.9组、ABI>1.3组、ABI>0.9～1.3组蛋白尿发生率分别是45.2%、31.5%、22.7%(P<0.05)。多因素回归分析结果显示,糖尿病发生下肢动脉病变的可能影响因素是年龄、血压、空腹血糖、总胆固醇、低密度脂蛋白胆固醇、UACR、肾小球滤过率和糖化血红蛋白(P<0.05)。结论糖尿病患者中ABI异常与UACR增高伴发率高,ABI异常还受年龄、血糖、血脂、血压等因素的影响。
Objective To investigate the relationship between ABI and urinary albumin to creatinine ratio (UACR) in type 2 diabetic patients. Methods A total of 469 patients with type 2 diabetes admitted to Department of Endocrinology in our hospital from January 2009 to November 2011 were collected for the determination of ABI and other related indicators. Select the same period in our hospital outpatient examination 38 cases of normal control group. To investigate the association between ABI abnormalities and UACR in type 2 diabetic patients. Results 469 cases of type 2 diabetes urinary protein abnormalities rate was 62.7%, ABI abnormal rate of 42.6%. The ABI abnormalities in clinical proteinuria group, microalbuminuria group and normal urine protein group were 41.4%, 23.2% and 14.9% respectively. ABI ≤ 0.9 group, ABI> 1.3 group, ABI> 0.9 ~ 1.3 histological albuminuria rates were 45.2%, 31.5%, 22.7% (P <0.05). Multivariate regression analysis showed that the possible influencing factors of lower extremity arterial disease were age, blood pressure, fasting blood glucose, total cholesterol, low density lipoprotein cholesterol, UACR, glomerular filtration rate and HbA1c (P <0.05). Conclusion Abnormal ABI and UACR in diabetic patients are associated with high incidence of ABI. Abnormal ABI is also affected by age, blood glucose, blood lipid, blood pressure and other factors.