论文部分内容阅读
低氧诱导因子是在低氧的肝癌细胞株细胞核提取物中发现的能特异性地结合于红细胞生成素基因增强子的寡核苷酸序列,其在氧感受和低氧信号转导机制中普遍起作用。该因子在缺血性心脏病中参与低氧应答反应,如缩小急性心肌梗死患者梗死范围,促进侧支循环形成,提高心肌缺血预适应能力,启动B型尿钠肽的心脏保护性作用、参与细胞凋亡过程、减轻心肌缺血/再灌注损伤等。
Hypoxia-inducible factor is an oligonucleotide sequence that is found in the nuclear extracts of hypoxic hepatocellular carcinoma cell lines that specifically binds to erythropoietin gene enhancers that are prevalent in mechanisms of oxygen sensing and hypoxia signaling kick in. This factor is involved in hypoxic response in ischemic heart disease, such as reducing infarct size in patients with acute myocardial infarction, promoting the formation of collateral circulation, improving myocardial ischemic preconditioning, initiating the cardioprotective effect of B-type natriuretic peptide, Participate in the process of apoptosis, relieve myocardial ischemia / reperfusion injury and so on.