目的探讨米索列醇用于预防产后出血的可行性。方法将足月阴道分娩产妇１８０例，随机分为观察组及对照组各９０例。观察组胎儿娩出后立即于阴道后穹窿放置米索列醇６００μｇ；对照组胎儿娩出后产妇立即肌住催产素２０ｕ。结果观察组第三产程平均为７２ｍｉｎ对照组平均为１０２ｍｉｎ，观察组较对照组缩短３０ｍｉｎ。观察组产后２ｈ内平均出血量为１４０４ｍｌ对照组产后２ｈ平均出血量为２１０５ｍｌ，经统计学处理有显著性差异（Ｐ＜００１）。结论米索前列醇可有效地缩短第三产程，减少产后出血 Objective To investigate the feasibility of misoprostol in preventing postpartum hemorrhage. Methods 180 cases of full-term vaginal delivery of mothers were randomly divided into observation group and control group of 90 cases. In the observation group, the misoprostol 600 μg was placed in the posterior fornix immediately after the delivery of the fetus; Results The average length of the third stage of labor in the observation group was 72min and the average value of the control group was 102min. The observation group was shorter than the control group by 30min. The observation group, the average amount of bleeding within 2h postpartum was 140  4ml 2h postoperative average blood loss was 210  5ml, statistically significant (P <0  01). Conclusion Misoprostol can shorten the third stage of labor and reduce postpartum hemorrhage