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目的探讨多烯磷酯酰胆碱注射液治疗弥漫甲状腺肿伴肝功能异常患者的疗效。方法选择我院2004年10月-2009年10月经确诊的毒性弥漫性甲状腺肿伴肝功能异常患者100例,分为治疗组和对照组,每组50例。两组病例在性别、年龄、甲亢病史、肝功能检查方面无显著差异。结果两组治疗后肝功能主要指标均有不同程度改善,与治疗前比较差异有统计学意义(P<0.05)。结论多烯磷酯酰胆碱注射液能对已破坏的肝细胞膜进行生理性修复,还有减少氧应激与脂质过氧化,从多方面保护肝细胞免受损害,而且又无毒性,治疗甲亢性肝损害具有疗程短、疗效显著的特点,所以有广泛的应用前景。
Objective To investigate the efficacy of polyene phosphatidylcholine injection in patients with diffuse goiter and liver dysfunction. Methods A total of 100 patients with venomous diffuse goiter complicated with liver dysfunction diagnosed in our hospital from October 2004 to October 2009 were divided into treatment group and control group with 50 cases in each group. There was no significant difference between the two groups in gender, age, history of hyperthyroidism and liver function test. Results The main indexes of liver function after treatment in both groups improved to some extent, with statistical significance (P <0.05). CONCLUSIONS: Polyene phosphatidylcholine injection can repair the damaged hepatocyte membrane physiologically and reduce oxygen stress and lipid peroxidation. It protects liver cells from damage in various aspects and is non-toxic Hyperthyroid liver damage has a short course of treatment, significant effect, so there is a wide range of applications.