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Darier 氏病(即毛囊角化病),是一种显性遗传的皮肤角化性疾病,以临床在脂溢部位上发生数量不等的油腻的非炎性的角化性丘疹以及组织学表现为表皮有棘层松解、有裂隙形成并有角化不良的圆体细胞和谷粒细胞为本病的特点。本病患者常有严重的进行性的病毒感染或细菌感染的倾向。作者在本文研究中认为这种合并感染的倾向可能与免疫系统不健全有关。作者观察了8例本病患者的体内外细胞免疫功能,并与相应年龄和性别的健康自愿者作了对照。研
Darier’s disease (follicular keratosis), a dominantly inherited keratosis of the skin, occurs clinically in a variable number of greasy non-inflammatory keratosis papules and histological findings There is a spinous layer on the epidermis loosening, the formation of fissures and keratinocytes poorly differentiated round and the characteristics of grain-based disease. The patients often have serious progressive viral infections or bacterial infections. In this study, the author thinks that the tendency of such coinfections may be related to the imperfect immune system. The authors observed cellular immunity in 8 patients in vitro and in vivo and compared them with healthy volunteers of corresponding age and sex. research