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早在1898年,J.H.van’t Hoff提出通过逆转质量作用,酶促肽合成应该是可能的.1938年,贝格曼(Bergman)和弗伦克尔康拉特(Fraenkel Conrat)首次用蛋白酶催化合成了所限定的肽.酶介导肽合成法与常规的方法相比有几项改进,如没有消旋作用、底
As early as 1898 JH van’t Hoff proposed that enzymatic peptide synthesis should be possible by reversing the mass effect. In 1938 Bergman and Fraenkel Conrat were first catalysed by proteases The defined peptides were synthesized.Enzyme-mediated peptide synthesis has several improvements over conventional methods such as no racemization,