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目的 :研究雷公滕醋酸乙酯提取物 (TWEE)对大鼠肾上腺的刺激作用。方法 :给大鼠连续 3 0dTWEE po( 2 5mg·kg-1bid) ,并设置泼尼松组和对照组 ,分别测定血清皮质酮含量、观察肾上腺组织学及超微结构变化。结果 :给药 3 0d后 ,TWEE组血清皮质酮含量明显升高 ;肾上腺皮质明显增厚 ,束状带细胞胞浆充满类脂质空泡 ;电镜观察束状带细胞胞浆中富含线粒体、光面内质网及大小不等的脂滴 ,线粒体嵴呈空泡状。结论 :TWEE能促进大鼠肾上腺皮质增生及促进皮质束状带细胞分泌皮质酮。
Objective: To study the stimulating effects of TWE on rats’ adrenal gland. Methods: The rats were given 30 days TWEEP (25 mg · kg-1bid), and the prednisone group and the control group were set up. The levels of serum corticosterone were measured respectively. The changes of adrenal histology and ultrastructure were observed. Results: Serum corticosterone levels in TWEE group were significantly increased after administration of TWE for 30 days. Adrenal cortex was significantly thicker and cytoplasm filled with lipid-like vacuoles. Electron microscopy showed that mitochondria were abundant in the cytoplasm of fascia. Smooth endoplasmic reticulum and lipid droplets of varying sizes, mitochondrial cristae were vacuolar. Conclusion: TWEE can promote rat adrenal cortex hyperplasia and promote the secretion of corticosterone in cortical zone cells.