戊型肝炎病毒(hepatitis E virus,HEV)是引起急性病毒性肝炎的病原体之一。HEV主要经粪-口途经传播,也有经输血传播的报道[1]。在发展中国家多因水源被HEV污染而发生戊型肝炎大规模流行,在发达国家主要是因摄入未煮熟的污染食物引起散发病例[2]。通常HEV感染后引起急性自限性肝炎,但是免疫功能低下的患者,合并HEV感染后可发生慢性化,甚至发展成肝硬化[3-5],孕妇感染HEV后病死率可高达20%[6]。最近还有报道,HEV感染后可引起一些严重的神[7-8] Hepatitis E virus (HEV) is one of the pathogens causing acute viral hepatitis. HEV is mainly transmitted by the fecal - oral route, there are also reports of blood transfusion [1]. In developing countries, hepatitis E epidemics occur mostly because HEVs are contaminated by water sources, and in developed countries, sporadic cases are mainly caused by ingestion of contaminated food [2]. Patients with acute self-limiting hepatitis usually develop HEV infection, but those with immunocompromised disease may develop chronic and even cirrhosis of the liver with a combination of HEV infection [3-5], with a mortality rate of up to 20% in pregnant women infected with HEV [6] ]. It has also been recently reported that HEV infection can cause some serious divine [7-8]