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目的探讨甘精胰岛素联合二甲双胍治疗2型糖尿病的临床疗效。方法选取沁水县龙港镇卫生院2008年4月—2013年4月收治的2型糖尿病患者20例,随机分为治疗1组和治疗2组,各10例。治疗1组应用甘精胰岛素联合二甲双胍治疗,治疗2组单纯应用二甲双胍治疗,疗程为16周。比较两组患者空腹血糖(FBG)、餐后2h血糖(2h PG)水平、24h尿糖定量变化情况及临床疗效。结果治疗1组总有效率为90.0%,高于治疗2组的70.0%,差异有统计学意义(P<0.05)。治疗后治疗1组患者FBG、2h PG以及24h尿糖定量低于治疗2组,差异有统计学意义(P<0.05)。结论甘精胰岛素联合二甲双胍能有效控制2型糖尿病患者血糖,有助于提高临床疗效。
Objective To investigate the clinical efficacy of glargine plus metformin in the treatment of type 2 diabetes. Methods Twenty cases of type 2 diabetic patients admitted from April 2008 to April 2013 in Longgang Town Hospital of Qinshui County were randomly divided into treatment group 1 and treatment group 2, with 10 cases each. Treatment group 1 with insulin glargine and metformin treatment, treatment group 2 metformin treatment alone, the course of treatment for 16 weeks. Fasting blood glucose (FBG), 2h postprandial blood glucose (2h PG), 24h urine glucose quantitative changes and clinical efficacy were compared between the two groups. Results The total effective rate in treatment group 1 was 90.0%, which was higher than that in treatment group 2 (70.0%), the difference was statistically significant (P <0.05). After treatment, the FBG, 2h PG and 24h urine glucose in treatment group 1 were lower than those in treatment group 2, the difference was statistically significant (P <0.05). Conclusion Glargine and metformin can effectively control the blood sugar in type 2 diabetic patients and improve the clinical curative effect.