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目的探讨geminin在胃癌组织中的表达及临床意义。方法采用免疫组化检测52例胃癌及癌旁组织中geminin的表达,分析geminin表达与患者临床病理特征的关系。根据免疫组化结果将胃癌患者分为高表达组(39例)和低表达组(13例),随访预后。结果 Geminin在胃癌组织中的阳性率为96.15%(50/52),高于癌旁组织的32.69%(17/52)(P<0.01)。Geminin表达与肿瘤大小及TNM分期有关(P<0.01),与患者年龄、性别及肿瘤分化程度无关(P>0.05)。高表达组患者术后生存率低于低表达组(P<0.05)。结论 Geminin在胃癌组织中高表达,有助于判断肿瘤的恶性程度及患者的预后。
Objective To investigate the expression of geminin in gastric carcinoma and its clinical significance. Methods Immunohistochemistry was used to detect the expression of geminin in 52 cases of gastric cancer and its adjacent tissues. The relationship between the expression of geminin and clinicopathological features was analyzed. According to the results of immunohistochemistry, gastric cancer patients were divided into high expression group (39 cases) and low expression group (13 cases), the follow-up prognosis. Results The positive rate of Geminin in gastric cancer tissues was 96.15% (50/52), which was higher than that in adjacent tissues (32.69%, 17/52) (P <0.01). Geminin expression was correlated with tumor size and TNM stage (P <0.01), but not with age, sex and tumor differentiation (P> 0.05). The survival rate of high expression group was lower than that of low expression group (P <0.05). Conclusion Geminin is overexpressed in gastric cancer, which can help to determine the malignancy and the prognosis of patients.