一种颅通定-聚离子复合凝胶释放体系,通过含药的壳多糖醋酸溶液使成球,然后再用羧甲基葡甘聚糖溶液粒面复合两步法制得。平均粒径(d)1.38-1.53mm,药含量可达62.8％。体外释放试验表明,在人工胃液中药物半释放T_(50)为45分钟,总释放达4小时,但在人工肠液中4小时仅释放药60％左右。考察了各种影响药物释放的因素。 A cranial fixed - poly ion composite gel release system, through the drug-containing chitin acetate solution into the ball, and then re-use of carboxymethyl glucomannan solution particle composite two-step process. The average particle size (d) 1.38-1.53mm, drug content of up to 62.8%. In vitro release test showed that in the artificial gastric juice, half the release of drug T_ (50) for 45 minutes, the total release of up to 4 hours, but in the artificial intestinal fluid release only about 60% 4 hours. Investigated a variety of factors that affect drug release.