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目的:分析2561例女性下生殖道人乳头瘤病毒(HPV)感染情况及探讨HPV感染的不同基因类型与宫颈病变的关系。方法:利用DAN杂交技术检测2561例妇科门诊和住院病例的下生殖道HPV并进行基因分型,搜集所有病例的检测结果,其中123例为宫颈上皮内瘤变(CIN)以上病变,对所得数据进行统计分析。结果:HPV总阳性率为26.08%(668/2561),不同年龄组别间阳性率有差异,但无明显趋势性;高危型HPV与低危型HPV各占检出构成比的87.3%和12.7%,高危型中以16型最多(23.6%),其次为52型(16.3%)、58型(15.0%);高危型HPV阳性率在CINⅠ、CINⅡ、CINⅢ、宫颈癌中分别为31.6%、53.1%、63.5%、75.0%,高危型HPV阳性率随着宫颈病变程度加重而递增。结论:HPV在女性中有一定的检出率,而高危型HPV感染是宫颈癌变的重要因素。
Objective: To analyze the genital HPV infection in 2561 women and explore the relationship between different HPV genotypes and cervical lesions. Methods: Genomic HPV was genotyped and genotyped in 2561 gynecological outpatients and inpatients by DAN hybridization. The detection results of all the cases were collected. Among them, 123 cases were diagnosed as cervical intraepithelial neoplasia (CIN). The data obtained conduct statistical analysis. Results: The total positive rate of HPV was 26.08% (668/2561). The positive rates of HPV in different age groups were different, but there was no significant trend. The detected proportions of high-risk HPV and low-risk HPV were 87.3% and 12.7% respectively (16.3%), type 58 (15.0%). The positive rate of high-risk HPV was 31.6% in CINⅠ, CINⅡ, CINⅢ and cervical cancer, 53.1%, 63.5%, 75.0%. The positive rate of high-risk HPV increased with the severity of cervical lesions. Conclusion: HPV has a certain detection rate in women, while high-risk HPV infection is an important factor in cervical cancer.