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为评价以水不溶性聚合物EC 为载体,用固体分散技术( 溶剂法) 制备难溶性药物酮洛芬缓释固体分散体,并进行DSC 和体外释放度研究。DSC 结果表明:药物与EC 比例为1∶2 和1∶3 时药物以非晶态存在于载体中。体外释放度试验结果表明,药物体外释药行为均符合Higuchi 方程;缓释效果与EC 量和固体分散体的粒径有主要关系,药物释放速率随EC 用量和粘度增加而减小;固体分散体粒径越小药物体外释放速率越快;在pH 6 .8 介质中的体外释放速率高于在pH1 .2 介质。
In order to evaluate the dispersibility of ketoprofen solid dispersion with solid dispersion technology (solvent method) using water-insoluble polymer EC as a carrier, DSC and in vitro release were studied. The DSC results show that the drug exists in the amorphous state in the carrier when the drug to EC ratio is 1: 2 and 1: 3. In vitro release test results show that the drug release behavior in vitro are in line Higuchi equation; sustained-release effect and the amount of EC and the size of the solid dispersion has a major relationship between drug release rate decreases with the increase of EC dosage and viscosity; solid dispersion The smaller the particle size, the faster the rate of drug release in vitro; the higher the release rate in vitro at pH6.8 than at pH1.2.