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目的 探讨一氧化氮 ( NO)吸入疗法对新生儿持续肺动脉高压 ( PPHN)的疗效、剂量、疗程及安全性。方法 对 1 0例 PPHN患儿进行了吸入 NO治疗 ,浓度以 2 0～ 40 ppm开始 ,6小时后降为 6 ppm持续 36～ 72小时 ,同时在吸入前后动态观测氧合情况、肺动脉压力、血压、心率及高铁血红蛋白 ( MHb)变化。结果 吸入 NO后 30分钟有 7例患儿氧合情况显著改善、肺动脉压力降低 ,对全身血压、心率并无明显影响 ;以 6 ppm维持 36～ 72小时 ,患儿氧合情况持续改善。结论 低浓度、短期吸入 NO能显著改善 PPHN患儿的氧合情况 ,但尚需对吸入NO的剂量、疗程、安全性等进行进一步研究
Objective To investigate the efficacy, dose, duration and safety of nitric oxide (NO) inhalation therapy for neonatal persistent pulmonary hypertension (PPHN). Methods A total of 10 children with PPHN were enrolled in the study. Nitric oxide (NO) treatment was given to children with PPHN at a concentration of 20-40 ppm. After 6 hours, they were reduced to 6 ppm for 36-72 hours. At the same time, oxygenation, pulmonary arterial pressure, , Heart rate and methemoglobin (MHb) changes. Results Thirty minutes after inhalation of NO, the oxygenation of 7 patients was significantly improved and the pulmonary pressure was decreased. No significant effect was found on systemic blood pressure and heart rate. At 6 to 36 hours, oxygenation continued to improve in children. Conclusions Low and short-term inhaled NO can significantly improve oxygenation in children with PPHN, but the dose, duration of treatment and safety of inhaled NO should be further studied