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目的研究白细胞介素7(IL-7)在多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者血清中的表达水平,探讨血清IL-7与PCOS的相关性及其意义。方法选取PCOS患者35例和对照组32例。用酶联免疫吸附试验(ELISA)法检测受试者血清中IL-7水平,并测量身高、体重并计算体重指数。测定血清卵泡刺激素(FSH)、黄体生成激素(LH)、睾酮(T)、空腹血糖(FBG)、空腹胰岛素(INS)。采用HOMA-IR公式计算胰岛素抵抗指数。结果 PCOS组血清IL-7水平明显高于对照组,差异有统计学意义(P<0.05)。PCOS组内IL-7水平与体重指数(BMI)、胰岛素抵抗指数(HOMA-IR)及LH/FSH比值呈正相关(P<0.05),与血清T水平无相关性(P>0.05)。结论 IL-7在PCOS患者血清中高表达,并与胰岛素抵抗有关,PCOS可能是一种慢性炎症性疾病。
Objective To investigate the expression of interleukin-7 (IL-7) in the serum of patients with polycystic ovary syndrome (PCOS) and to explore the relationship between serum IL-7 and PCOS and its significance. Methods 35 cases of PCOS patients and 32 cases of control group were selected. Serum levels of IL-7 were measured by enzyme-linked immunosorbent assay (ELISA), and height, weight and body mass index were calculated. Serum FSH, LH, T, FBG and INS were measured. Insulin resistance index was calculated using HOMA-IR formula. Results The level of serum IL-7 in PCOS group was significantly higher than that in control group (P <0.05). The level of IL-7 in PCOS group was positively correlated with BMI, HOMA-IR and LH / FSH (P <0.05), but not with serum T level (P> 0.05). Conclusion IL-7 is highly expressed in sera of PCOS patients and is related to insulin resistance. PCOS may be a chronic inflammatory disease.