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目的研究分析腹腔镜手术治疗前后子宫内膜异位患者血浆微小RNA(miR)及红细胞多项指标的变化情况。方法选取2011年9月至2013年5月采用腹腔镜手术进行治疗的37例子宫内膜异位症患者为观察组,并以同时期采用开腹手术治疗的37例患者为对照组,然后将两组患者手术前与手术后1、3、5 d的的多项血浆miR及红细胞指标进行比较。结果观察组术后1、3、5 d的血浆miR-20a、miR-21及miR-199a均高于对照组,红细胞免疫指标均优于对照组,红细胞黏度相关指标则均显著低于对照组,P均<0.05,均有显著性差异。结论腹腔镜手术治疗后子宫内膜异位患者血浆miR呈现持续改善,而红细胞多项指标的变化也更为明显。
Objective To analyze the changes of multiple micro-targets of plasma micro-RNA (miR) and erythrocytes in patients with endometriosis before and after laparoscopic surgery. Methods Seventy-seven patients with endometriosis undergoing laparoscopic surgery from September 2011 to May 2013 were selected as the observation group and 37 patients treated with laparotomy during the same period as the control group. A number of plasma miRs and erythrocyte indices were compared between preoperative and postoperative 1, 3, 5 days after operation. Results The plasma levels of miR-20a, miR-21 and miR-199a in the observation group at 1, 3 and 5 days after operation were significantly higher than those in the control group. The indexes of erythrocyte immunity were superior to those of the control group, while those of the erythrocyte viscosity were significantly lower than those of the control group , P <0.05, there were significant differences. Conclusion The plasma miR in patients with endometriosis after laparoscopic surgery continues to improve, while the changes of multiple indicators of red blood cells are also more obvious.