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目的应用回顾性分析方法,探讨骨髓增生异常综合征(MDS)患者医院感染的危险因素、耐药性和预防措施。方法收集浙江省温州医科大学附属第一医院住院MDS患者736例,其中发生医院感染158例(21.5%);对年龄、病程、中性粒细胞计数、侵入性治疗、合并其他疾病、医院感染部位、病原菌进行评估和分析。结果 MDS患者医院感染发生率较高;感染因素与年龄(r=0.78)、住院天数(r=0.69)、侵入性治疗(r=0.61)、合并其他疾病(r=0.72)呈正相关(P<0.05);与中性粒细胞计数(r=-0.74)呈负相关(P<0.05)。感染部位以呼吸道为主(46.8%),其次为血流感染(16.5%)、胃肠道(8.9%)和泌尿道(7.0%);病原体多分布于痰液、血液、胃肠道和泌尿道。结论 MDS患者易发生医院感染,控制易感因素是预防医院感染的有效方法。
Objective To investigate the risk factors, drug resistance and preventive measures of nosocomial infection in patients with myelodysplastic syndrome (MDS) by retrospective analysis. Methods A total of 736 inpatients with MDS were enrolled in the First Affiliated Hospital of Wenzhou Medical University, Zhejiang Province, of which 158 (21.5%) were hospitalized. The age, course of disease, neutrophil count, invasive treatment, other diseases combined with nosocomial infection , Pathogen assessment and analysis. Results The incidence of nosocomial infections in MDS patients was high. The infection factors were positively correlated with age (r = 0.78), hospitalization days (r = 0.69), invasive treatment (r = 0.61) and other diseases (r = 0.72) 0.05), but negatively correlated with neutrophil count (r = -0.74) (P <0.05). The main respiratory tract was respiratory tract (46.8%), followed by bloodstream infection (16.5%), gastrointestinal tract (8.9%) and urinary tract (7.0%). Pathogen was mainly distributed in sputum, blood, gastrointestinal tract and urinary tract Road. Conclusion MDS patients prone to nosocomial infection, control of susceptibility factors is an effective way to prevent nosocomial infections.