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目的观察放射性125I粒子植入联合高频热疗治疗晚期肺癌的临床疗效。方法收集医院晚期肺癌确诊患者216例,随机分为观察组和对照组各108例。要求所有患者接受入院检查及常规对症治疗,观察组采用放射性125I粒子植入联合高频热疗治疗,对照组使用单纯高频热疗治疗。治疗后比较2组患者疗效及生活质量。结果观察组达到部分缓解患者所占比例高于对照组,处于进展状态的患者所占比例小于对照组,差异均有统计学意义(P<0.05),2组达到完全缓解或是无变化患者所占比例比较差异无统计学意义(P>0.05)。观察组患者病情好转率高于对照组,恶化率低于对照组,差异均有统计学意义(P<0.05);2组病情稳定率差异无统计学意义(P>0.05)。结论放射性125I粒子植入联合高频热疗治疗晚期肺癌较单独高频热疗疗效更好,减缓肿瘤恶化程度,提高患者的生存质量。
Objective To observe the clinical efficacy of radioactive 125I seed implantation combined with high frequency hyperthermia in the treatment of advanced lung cancer. Methods Totally 216 patients with advanced lung cancer diagnosed in the hospital were randomly divided into observation group (108 cases) and control group (108 cases). All patients were required to undergo admission examination and conventional symptomatic treatment. The observation group was treated with radioactive 125I seed implantation combined with high frequency hyperthermia, while the control group was treated with simple high frequency hyperthermia. After treatment, the efficacy and quality of life of the two groups were compared. Results The proportion of patients with partial remission in the observation group was higher than that in the control group, and the proportion of patients in the progress state was less than that in the control group (P <0.05). The patients in the two groups achieved complete remission or no change There was no significant difference in proportion (P> 0.05). The rate of improvement in the observation group was higher than that in the control group, and the rate of deterioration was lower than that in the control group (P <0.05). There was no significant difference in the stability of the two groups (P> 0.05). Conclusion Radiotherapy 125I seeds combined with high frequency hyperthermia in the treatment of advanced lung cancer better than single high frequency hyperthermia, reduce the degree of tumor deterioration and improve the quality of life of patients.