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目的探讨彩色多普勒检测膀胱癌血流及其与CD105标记的血管密度的关系,以积累经验,指导临床工作。方法收集我院收治的112例膀胱癌患者,术前应用彩色多普勒超声检查,计算阻力指数(RI),术后采用免疫组织化学技术检测CD105标记的微血管密度(MVD),探讨RI及MVD在不同临床特征中的意义及RI与MVD表达的关系。结果 RI与MVD值均与肿瘤的浸润程度及肿瘤的分级有关;RI与MVD值在膀胱癌中表达呈负相关。结论手术前检测RI值可以反应膀胱癌的血管形成情况,且与肿瘤的浸润及分级相关,手术前检测RI对于判断肿瘤的预后和指导临床治疗可能具有一定价值。
Objective To explore the relationship between color Doppler flowmetry and CD105-labeled vascular density in order to gain experience and guide clinical work. Methods One hundred and twelve cases of bladder cancer were collected from our hospital. Color Doppler ultrasound was used to calculate the resistance index (RI) before operation. The expression of CD105 - Significance in different clinical features and the relationship between RI and MVD expression. Results RI and MVD were related to the degree of tumor invasion and tumor grade. The expression of RI and MVD in bladder cancer was negatively correlated. Conclusion The value of RI before operation can reflect the angiogenesis of bladder cancer and is related to the infiltration and grading of the tumor. The detection of RI before operation may be of value in judging the prognosis of the tumor and guiding the clinical treatment.