目的　报道颅底肿瘤显微外科手术治疗的临床疗效。　方法　回顾分析显微外科手术治疗颅底肿瘤 2 6例的临床特点和总结手术体会。　结果　 2 6例颅底肿瘤中 ,手术全切除 2 2例 ,次全切除4例 ,死亡 2例。术后随访到 2 4例 ,脑神经损害或症状加重 3例 ,其余病例全部好转或痊愈。全切除的病例术后 3～ 6个月及 1年复查 MRI均未见肿瘤复发。　结论　眶上入路和眶颅颧入路是前、中颅底肿瘤较理想的手术径路 ,颅中、后窝肿瘤的手术治疗应把经岩骨乙状窦前入路作为主要选择 ,颅底和硬脑膜重建是颅底手术成败的关键 Objective To report the clinical efficacy of microsurgery in the treatment of skull base tumors. Methods Retrospective analysis of microsurgery in the treatment of skull base tumors in 26 cases of clinical features and summary of surgical experience. Results In 26 cases of skull base tumors, total resection was performed in 22 cases, subtotal resection in 4 cases and death in 2 cases. Follow-up to 24 cases, 3 cases of cranial nerve damage or symptoms aggravated, the rest of the cases all improved or healed. Total resection of the cases 3 to 6 months after surgery and 1 year review MRI showed no tumor recurrence. Conclusions Supraorbital approach and orbital cranial zygomatic approach is an ideal surgical approach to the anterior and middle skull base tumors. Surgical treatment of the tumors in the midcranial and posterior fossa tumors should be based on the anterior approach of the petrous ostium, And dural reconstruction is the key to the success or failure of skull base surgery