我科自1975～1989年收治血培养阳性新生儿败血症45例。有围产期危险因素的占32％,入侵途径以脐炎和脓疱疮多见,临床表现不典型,多以发热、黄疸为主诉。病原菌以葡萄球菌居首位占75％,大肠杆菌次之占9％,在葡萄球菌败血症中以白葡菌占多数,达56％。机体免疫功能降低是造成机会菌感染的重要原 My department from 1975 to 1989 admitted to blood culture positive neonatal sepsis in 45 cases. Perinatal risk factors accounted for 32% of the invasion to omphalitis and impetigo more common, clinical manifestations of atypical, mostly fever, jaundice chief complaint. Staphylococcus aureus accounted for 75% of the total number of pathogens and Escherichia coli accounted for 9%, while Staphylococcus aureus accounted for 56% of the total in staphylococcal sepsis. Reduced immune function is an important cause of opportunistic bacterial infection