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目的 探讨磷酸己糖异构酶 (GPI)在肿瘤诊断及病情监测中的临床应用价值。方法 GPI活性测定采用改良的化学比色法。结果 对 718例血清标本GPI活性测定发现 ,恶性肿瘤组血清CPI活性 (149.2 6± 75 .2 3IU/L)显著高于健康对照组 (5 3 .96± 2 3.78IU/L)和良性疾病组 (75 .93± 35 .6 7IU/L) ,P <0 .0 5。肺癌、肝癌、胰腺癌和胆囊癌的检测阳性率分别为 88 46 %、83 87%、82 6 1%和 79 31% ,明显高于其它肿瘤组、良性疾病组和正常对照组 (P <0 .0 5 )。进展期及出现远处转移的肿瘤病人血清GPI活性 (197.2 6± 93.74IU/L)明显高于缓解期病人 (84.5 7± 43.38IU/L) ,P <0 .0 1。经手术、放疗或化疗后病人血清GPI活性明显降低 ,尤以手术后GPI活性降低最为明显。结论 ①GPI活性检测可用于恶性肿瘤尤其是肺癌、肝癌、胰腺癌和胆囊癌的辅助诊断和病情监测。②改良的GPI活性测定方法简便、快速、稳定、经济 ,便于在基层单位推广。
Objective To investigate the clinical value of hexose phosphate hexose isomerase (GPI) in tumor diagnosis and disease monitoring. Methods GPI activity was determined using a modified chemometric method. Results Serum CPI activity in 718 serum samples was significantly higher than that in healthy controls (59.26 ± 75.32IU / L) and benign disease group (75.93 ± 35.67 IU / L), P <0.05. The positive rates of lung cancer, liver cancer, pancreatic cancer and gallbladder cancer were 88 46%, 83 87%, 82 6 1% and 79 31%, respectively, which were significantly higher than those in other tumor group, benign disease group and normal control group .0 5). Serum GPI activity in patients with advanced and distant metastasis (197.2 ± 93.74 IU / L) was significantly higher than that in patients with remission (84.5 7 ± 43.38 IU / L), P <0.01. After operation, radiotherapy or chemotherapy patients serum GPI activity was significantly lower, especially after surgery GPI activity was most obvious. Conclusion ① The activity of GPI can be used in the diagnosis and monitoring of malignant tumors, especially in lung cancer, liver cancer, pancreatic cancer and gallbladder cancer. ② improved GPI activity determination method is simple, fast, stable, economical, easy to promote in the grass-roots units.