论文部分内容阅读
按文献方法合成了抗肿瘤药来那替尼,并合成了5个有关物质:N-[4-[3-氯-4-(吡啶-2-甲氧基)苯胺基]-3-氰基-7-乙氧基喹啉-6-基]甲酰胺(A)、N1-[4-[3-氯-4-(吡啶-2-甲氧基)苯胺基]-3-氰基-7-乙氧基喹啉-6-基]-N2,N2-二甲基乙二酰胺(B)、2-[4-[3-氯-4-(吡啶-2-甲氧基)苯胺基]-3-氰基-7-乙氧基喹啉-6-基]氨基-2-氧代乙酸(C)、3-氰基-4-[3-氯-4-(吡啶-2-甲氧基)苯胺基]-7-乙氧基-6-[(1-甲基吡咯烷-2-亚基)氨基]喹啉(D)和3-氰基-4-[3-氯-4-(吡啶-2-甲氧基)苯胺基]-7-乙氧基-6-(2-羟基-5-氧代吡咯烷-1-基)喹啉(E),经MS、1H NMR和13C NMR确证结构。
The antitumor drug neratinib was synthesized by the literature method and five related substances were synthesized: N- [4- [3-chloro-4- (pyridin-2-methoxy) anilino] (A), N1- [4- [3-chloro-4- (pyridin-2-methoxy) anilino] -3-cyano-7 -ethoxyquinolin-6-yl] -N2, N2- dimethyl ethanediamide (B), 2- [4- [3 -chloro- 4- (pyridin- 2-methoxy) anilino] Amino-2-oxoacetic acid (C), 3-cyano-4- [3 -chloro-4- (D) and 3-cyano-4- [3-chloro-4- (2-hydroxy-5-oxopyrrolidin- 1 -yl) quinoline (E) was obtained by MS, 1 H NMR and 13 C NMR confirmed the structure.