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目的:探讨新疆维吾尔族人群基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)基因rs17577多态性与心肌梗死的相关性。方法:经皮冠状动脉造影确诊维吾尔族心肌梗死患者338例(MI组)和同期冠状动脉造影阴性患者309例为对照组,采用聚合酶链反应-限制性片段长度多态性方法行MMP-9基因rs17577多态性分析。结果:MMP-9基因rs17577多态性位点在MI组和对照组基因型频率分别为:A/A型13.31%和5.18%,G/A型37.87%和39.8%,G/G型48.82%和55.02%。A/A基因型频率(13.31%,5.18%)及A型等位基因频率(32.25%,25.08%)分布差异有统计学意义(χ2=11.58,P=0.001;χ2=8.08,P=0.004)。用Logistic回归分析校正了年龄、性别、吸烟、高血压、高脂血症等传统风险因素干扰后,MMP-9基因A/A基因型仍是心肌梗死发生的独立风险因素。结论:A/A基因型和A型等位基因可能增加新疆维吾尔族人群发生心肌梗死的风险。
Objective: To investigate the association of rs17577 polymorphism of matrix metalloproteinase-9 (MMP-9) gene with myocardial infarction in Xinjiang Uygur population. Methods: 338 cases of myocardial infarction in Uighur diagnosed by percutaneous coronary angiography (MI group) and 309 patients with negative angiographic coronary angiography at the same period were taken as the control group. The expression of MMP-9 was detected by polymerase chain reaction-restriction fragment length polymorphism Polymorphism analysis of rs17577 gene. Results: The frequencies of rs17577 polymorphism of MMP-9 gene in MI group and control group were 13.31% and 5.18% for A / A type, 37.87% and 39.8% for G / A type and 48.82% for G / G type respectively And 55.02%. The frequencies of A / A genotype (13.31%, 5.18%) and A allele (32.25%, 25.08%) were statistically different (χ2 = 11.58, P = 0.001; χ2 = 8.08, P = 0.004) . Logistic regression analysis corrected the age, gender, smoking, hypertension, hyperlipidemia and other traditional risk factors interference, MMP-9 gene A / A genotype is still an independent risk factor for myocardial infarction. Conclusion: A / A genotype and A allele may increase the risk of myocardial infarction in Uygur population of Xinjiang.