动脉粥样硬化(AS)的发生、发展及其发病机制是研究心血管疾病的重要课题之一。近年的许多研究表明,AS患者血清中脂质过氧化物(LPO)的含量高于健康人;AS病变部位LPO的含量也高于正常部位。并且认为LPO是AS的始动因子。在许多临床和实验治疗研究中亦发现,使用抗氧化药物和过氧化自由基清除剂,而不用降脂药物,同样可以抑制AS的产生和发展。所以LPO作为AS发生发展的重要因子之一,受到国内外学者的关注,并作为抗AS治疗和药物研究中的方向。一、LPO对内皮细胞的直接损害作用在AS形成过程中,血液中的LPO直接作用于内皮细胞,并且在AS斑块区内 The occurrence, development and pathogenesis of atherosclerosis (AS) are one of the most important topics in the study of cardiovascular diseases. In recent years, many studies have shown that AS patients with serum lipid peroxides (LPO) higher than healthy people; AS lesion LPO content is also higher than normal. And think LPO is the starting factor of AS. In many clinical and experimental treatment studies also found that the use of anti-oxidant drugs and peroxide free radical scavenger, without lipid-lowering drugs, can also inhibit the production and development of AS. Therefore, LPO as one of the important factors in the development of AS has attracted the attention of scholars at home and abroad and serves as the direction of anti-AS therapy and drug research. First, LPO direct damage to endothelial cells in the role of AS in the formation of blood LPO directly on endothelial cells, and in the AS plaque area