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Pluripotency-associated factors and their rivals,lineage specifers,have long been considered the determining factors for the identity of pluripotent and differentiated cells,respectively.Therefore,factors that are employed for cellular reprogramming in order to induce pluripotency have been identifed mainly from embryonic stem cell(ESC)-enriched and pluripotency-associated factors.Recently,lineage specifers have been identifed to play important roles in orchestrating the process of restoring pluripotency.In this review,we summarize the latest discoveries regarding cell fate conversion using pluripotency-associated factors and lineage specifers.We highlight the value of the‘‘seesaw’’model in defning cellular identity,opening up a novel scenario to consider pluripotency and lineage specifcation.
Pluripotency-associated factors and their rivals, lineage specifiers, have long been considered the deciding factors for the identity of pluripotent and differentiated cells, respectively. Beforefore, factors that are employed for cellular reprogramming in order to induce pluripotency have been identified primarily from embryonic stem cell (ESC) -enriched and pluripotency-associated factors.Recently, lineage specifiers have been identified to play important roles in orchestrating the process of restoring pluripotency. this review, we summarize the latest discoveries regarding cell fate conversion using pluripotency-associated factors and lineage specifers.We highlight the value of the’seesaw’model in defning cellular identity, opening up a novel scenario to consider pluripotency and lineage specifcation.