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目的:观察补肾养阴清火法治疗慢性牙周炎的临床疗效和对牙周局部炎性免疫因子的影响,探讨中药辅助治疗慢性牙周炎的临床可行性。方法:慢性牙周炎患者分成试验组和对照组,对照组进行牙周基础治疗和根面平整,试验组在牙周基础治疗1个月后口服中药调理,3个月后比较两组治疗前后牙周探诊深度(PD)、牙龈出血指数(BI)和龈沟液中白介素-1β(IL-1β)、白细胞介素-6(IL-6)的变化。结果:试验组和对照组PD、BI组内比较,治疗3个月均比治疗前明显减少(P<0.05),但两组间治疗前后差值比较,差异无统计学意义。试验组和对照组龈沟液中IL-1β和IL-6组内比较,治疗3个月均比治疗前明显降低(P<0.05),两组间治疗前后差值比较,差异有统计学意义(P<0.05)。中医主症候群和次症候群评分试验组治疗3个月较治疗前降低明显,差异有统计学意义(P<0.05),次症候群两组间治疗前后差值比较,差异有统计学意义(P<0.05)。结论:牙周基础治疗和根面平整是牙周治疗的有效方法,中药调理可以调节机体免疫,辅助降低龈沟液中炎性因子的水平。
Objective: To observe the clinical efficacy of Bushen Yangyinqinghuo treatment of chronic periodontitis and its effect on periodontal local inflammatory immune factors, and to explore the clinical feasibility of traditional Chinese medicine adjuvant treatment of chronic periodontitis. Methods: The patients with chronic periodontitis were divided into experimental group and control group. The control group received periodontal basic treatment and root surface formation. The experimental group was given oral Chinese medicine for one month after basic periodontal treatment. After three months, the two groups were compared before and after treatment Periodontal exploration depth (PD), gingival bleeding index (BI), and the levels of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in gingival crevicular fluid. Results: Compared with before treatment, the PD group and the BI group in the experimental group and the control group were significantly reduced (P <0.05) 3 months after treatment, but there was no significant difference between the two groups before and after treatment. The levels of IL-1β and IL-6 in gingival crevicular fluid of experimental group and control group were significantly lower than those before treatment (P <0.05), and the differences between before and after treatment were statistically significant (P <0.05). The TCM syndrome and sub-syndrome score in the experimental group decreased significantly 3 months after treatment compared with before treatment, the difference was statistically significant (P <0.05). The difference between the two groups was statistically significant (P <0.05 ). Conclusion: The basic periodontal treatment and the root surface formation are effective methods for periodontal treatment. The Chinese medicine conditioning can regulate the immunity of the body and help to reduce the level of inflammatory cytokines in the gingival crevicular fluid.