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很多疾病均可导致疼痛，如何有效缓解疼痛一直是困扰临床医师的难题。研究发现，P物质是一种十一氨基酸多肽，广泛地分布于神经系统和其他外周组织器官内，其 G蛋白偶联受体神经激肽1受体密集分布于脊髓背角浅层。 P物质及其受体 NK-1受体与疼痛有密切关系。 P物质作为兴奋靶组织器官的神经递质，从初级感觉传入纤维终末释放，介导痛觉传递。 P物质和 NK-1R结合也可以介导痛觉效应。 P物质经酶解产生的N端片段和NK-1受体拮抗剂则产生镇痛作用。“,”Many diseases can cause pain,and how to effectively alleviate pain has been plaguing clinical doctors.Studies have showed that substance P( SP) is an undecapeptide,showing a widespread distribution in both nervous system and other peripheral tissues and organs.Its G-protein coupled receptor neurokinin-1 receptor(NK-1R) is densely distributed in the spinal dorsal horn of shallow.SP and NK-1R are closely asso-ciated with pain.SP,as a neurotransmitter,has an exciting effect on the target tissues and organs.SP released from the peripheral terminals of the primary sense afferents plays an important role in the process of mediating pain transmission.SP combining with NK-1R can also regulate pain effect.N-terminal fragments of SP pro-duced by enzyme degradation and NK-1R antagonists have analgesic action.